Chatterji P, Douchin J, Giroux V.

Demystifying the differences between Tumor-Initiating Cells and Cancer Stem Cells in Colon Cancer

Current Colorectal Cancer Report, in press



Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran PM, Hara T, Sahu V, Kasagi Y, Kikuchi O, Tanaka K, Giroux V, Muir AB, Whelan KA, Ohashi S, Naganuma S, Klein-Szanto AJ, Shinden Y, Sasaki K, Omoto I, Kita Y, Muto M, Bass AJ, Diehl JA, Ginsber GG, Doki Y, Mori M, Uchikado Y, Origami T, Avadhani NG, Basu D, Rustig AK, Natsugoe S.

Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells

Cellular and Molecular Gastroenterology and Hepatology, in press 

Giroux V, Stephan J, Chatterji P, Rhoades B, Wileyto EP, Klein-Santo AJ, Lengner CJ, Hamilton KE, Rustgi AK.

Mouse intestinal Krt15+ crypt cells are radio-resistant and tumor initiating

Stem Cell Reports 2018, 10(6):1947-1958.

Kasagi Y, Chandramoulesswaran P, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias J, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H.

The esophageal organoid system reveals functional interplay between Notch and cytokines in reactive epithelial changes.

Cellular and Molecular Gastroenterology and Hematology 2018; 5(3):333-352.


Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, Long A, Darling D, Que J, Yang Y, Katz J, Wileyto EP, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto AJ, Diehl AJ, Bass A, Wong KK, Rustgi AK, and Nakagawa H.

Interplay between Notch1 and Notch3 promotes EMT, tumor initiation and cancer cell heterogeneity in squamous cell carcinoma.

Nature Communications 2017; 8(1):1758.


Giroux V and Rustgi AK.

Metaplasia: tissue injury adaptation and precursor to the dysplasia-cancer sequence.

Nature Reviews Cancer 2017; 17(10):594-604.


Giroux V, Lento AA, Islam MM, Pitarresi JR, Kharbanda A, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi.

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.

Journal of Clinical Investigation 2017; 127(6):2378-2391.


Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM, Nakagawa H.

Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis.

Gut 2017; 66(7):1197-1207.


Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK.

Loss of stromal IMP1 promotes a tumorigenic microenvironment in the colon.

Molecular Cancer Research 2015; 13(11):1478-86.


Long A, Giroux V, Whelan KA, Hamilton KE, Tétreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK.

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma.

Carcinogenesis 2015; 36(5):598-606.


Vega ME, Giroux V, Natsuizaka M, Liu M, Klein-Szanto AJ, Stairs DB, Nakagawa H, Wang KK, Wang TC, Lynch JP, Rustgi AK.

Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4.

Cell Cycle 2014; 13(24):3857-66.


Groulx JF, Giroux V, Beauséjour M, Boudjadi S, Basora N, Carrier JC, Beaulieu JF.

Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cells.

Carcinogenesis 2014; 35(6):1217-27.


Bernatchez G, Giroux V, Lassalle T, Carpentier AC, Rivard N, Carrier JC.

ERRα metabolic nuclear receptor controls growth of colon cancer cells.

Carcinogenesis 2013; 34(10):2253-2261.


Giroux V, Bernatchez G, Carrier JC.

Chemopreventive effect of ERβ-Selective agonist on intestinal tumorigenesis in Apc(Min/+) mice.

Molecular Carcinogenesis 2011; 50(5):359-369.


Giroux V, Lemay F, Bernatchez G, Robitaille Y, Carrier JC.

Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice.

International Journal of Cancer 2008; 123(2):303-11.