Gastrointestinal Stem Cells
Tissue Regeneration & Cancer
We previously identified a new Keratin 15 (Krt15)+ esophageal stem cells (Giroux et al. 2017). These cells are necessary for normal tissue homeostasis, radio-resistant and contribute to epithelial regeneration following tissue injury.
1) Identify the biological pathways responsible for the distinct biological properties of Krt15+
esophageal stem cells;
2) Investigate the contribution of these cells to establishment of treatment resistance in cancer patients.
We recently described a Keratin 15 (Krt15)+ intestinal crypt cell population with self-renewal and multipoint properties (Giroux et al. 2018). Krt15+ intestinal cells are also radio-resistant and display regenerative and tumor initiating capacities.
1) Investigate the role of Krt15+ cells in intestinal inflammation;
2) Study further the tumor-initing capacities of these cells.